Pivalophenone imine as a benzonitrile surrogate for directed C–H bond functionalization† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01732d Click here for additional data file.
نویسندگان
چکیده
Pivalophenone N–H imine has been found to serve as a prominent substrate for directed C–H alkylation and arylation reactions with alkyl bromides and aryl chlorides, respectively, under cobalt–N-heterocyclic carbene (NHC) catalysis. Unlike the case of the parent pivalophenone imine, the increased steric bulk of the resulting ortho-substituted pivalophenone imines allows them to undergo clean imine-to-nitrile conversion under peroxide photolysis or aerobic copper catalysis conditions. Overall, these two-step transformations offer convenient synthetic methods for ortho-functionalized benzonitriles.
منابع مشابه
Rhodium-catalyzed C–H functionalization-based approach to eight-membered lactams† †Electronic supplementary information (ESI) available: Data for new compounds and experimental procedures and theoretical studies on mechanisms. CCDC 979559 and 990983. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc00092k Click here for additional data file. Click here for additional data file.
Laboratory of Molecular Recognition an Zhejiang University, Hangzhou 310027, Zh ac.cn State Key Laboratory of Organometallic C Chemistry, Chinese Academy of Sciences, [email protected] Shanghai Key Laboratory of Magnetic Reson Normal University, Shanghai 200062, P. R. † Electronic supplementary information ( and experimental procedures and theor 979559 and 990983. For ESI and crystallo format s...
متن کاملIntermolecular oxidative decarbonylative [2 + 2 + 2] carbocyclization of N-(2-ethynylaryl)acrylamides with tertiary and secondary alkyl aldehydes involving C(sp3)–H functionalization† †Electronic supplementary information (ESI) available. CCDC 1438591. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc02451c Click here for additional data file. Click here for additional data file.
متن کامل
Rhodium(i)-catalyzed stereoselective [4+2] cycloaddition of oxetanols with alkynes through C(sp3)–C(sp3) bond cleavage† †Electronic supplementary information (ESI) available. CCDC 1512439 and 1512440. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc05246k Click here for additional data file. Click here for additional data file.
متن کامل
Formation of a C–C double bond from two aliphatic carbons. Multiple C–H activations in an iridium pincer complex† †Electronic supplementary information (ESI) available: Experimental details, characterization data, Cartesian coordinates, additional graphs and computational details. CCDC 1024127–1024129. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4sc03839h Click here for additional data file. Click here for additional data file.
متن کامل
Piezochromism and hydrochromism through electron transfer: new stories for viologen materials† †Electronic supplementary information (ESI) available: Synthetic procedures, bond data. CCDC 1428498. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc04579k Click here for additional data file. Click here for additional data file.
Shanghai Key Laboratory of Green Chemi Chemistry and Molecular Engineering, Eas Zhongshan Road, Shanghai 200062, P. R. C Center for High Pressure Science and Tech Road, Shanghai 201203, P. R. China. E-mai State Key Laboratory of Superhard Materia Changchun, Jilin 130012, P. R. China † Electronic supplementary information bond data. CCDC 1428498. For ESI and electronic format see DOI: 10.1039/c6...
متن کامل